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Eur J Nutr. 2017 Dec;56(Suppl 3):37-42. doi: 10.1007/s00394-017-1580-2.

Dietary guidance for lutein: consideration for intake recommendations is scientifically supported.

Author information

1
Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
2
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
3
Science and International Affairs, Council for Responsible Nutrition-International, Washington, DC, USA.
4
Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA. jwerdman@illinois.edu.
5
Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, 455 Bevier Hall, 905 S. Goodwin Ave, Urbana, IL, 61801, USA. jwerdman@illinois.edu.

Abstract

Lutein, a yellow xanthophyll carotenoid found in egg yolks and many colorful fruits and vegetables, has gained public health interest for its putative role in visual performance and reducing the risk of age-related macular degeneration. The National Academies of Sciences, Engineering and Medicine's recommended Dietary Reference Intakes (DRIs) focus on preventing deficiency and toxicity, but there is a budding interest in establishing DRI-like guidelines for non-essential bioactives, like lutein, that promote optimal health and/or prevent chronic diseases. Lupton et al. developed a set of nine criteria to determine whether a bioactive is ready to be considered for DRI-like recommendations. These criteria include: (1) an accepted definition; (2) a reliable analysis method; (3) a food database with known amounts of the bioactive; (4) cohort studies; (5) clinical trials on metabolic processes; (6) clinical trials for dose-response and efficacy; (7) safety data; (8) systematic reviews and/or meta-analyses; (9) a plausible biological rationale. Based on a review of the literature supporting these criteria, lutein is ready to be considered for intake recommendations. Establishing dietary guidance for lutein would encourage the consumption of lutein-containing foods and raise public awareness about its potential health benefits.

KEYWORDS:

Bioactives; Intake recommendations; Lutein; Macular degeneration; Visual performance

PMID:
29149368
PMCID:
PMC5715043
DOI:
10.1007/s00394-017-1580-2
[Indexed for MEDLINE]
Free PMC Article

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