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Phys Chem Chem Phys. 2017 Dec 20;20(1):63-67. doi: 10.1039/c7cp06344j.

Calcium-dependent hydrolysis of supported planar lipids was triggered by honey bee venom phospholipase A2 with the right orientation at the interface.

Author information

1
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. lxl@seu.edu.cn.

Abstract

Hydrolysis of planar phospholipids catalyzed by honey bee venom phospholipase A2 (bvPLA2) was studied. Experiments demonstrated that Ca2+ ions mediated between the lipids and bvPLA2, induced reorientation of bvPLA2, and activated hydrolysis. One of the hydrolysis products, fatty acids, was desorbed, and the other one, lysophospholipids, self-organized at the interface.

PMID:
29149234
DOI:
10.1039/c7cp06344j
[Indexed for MEDLINE]

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