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BMC Proc. 2017 Oct 3;11(Suppl 11):11. doi: 10.1186/s12919-017-0079-4. eCollection 2017.

Personalized medicine and Hispanic health: improving health outcomes and reducing health disparities - a National Heart, Lung, and Blood Institute workshop report.

Author information

1
Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 10188, Bethesda, MD 20892-7936 USA.
2
Department of Family Medicine, Oregon Health and Science University, 318 SW Sam Jackson Park Rd, Portland, OR 97239 USA.
3
Kaiser Permanente Northwest Center for Health Research, 3800 N. Interstate Ave, Portland, OR 97227 USA.
4
Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB2 Room 5M, Baltimore, MD 21231 USA.
5
University of Arizona Health Sciences, 1295 North Martin Avenue, PO Box 210202, Tucson, AZ 86721 USA.
6
Columbia University, Mailman School of Public Health, 722 West 168th Street, New York, NY 10032 USA.
7
Office of Minority Health, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993 USA.
8
National Alliance for Hispanic Health, 1600 P St NW, Washington, DC 20009 USA.
9
National Center for Health Statistics, 3311 Toledo Road, Hyattsville, MD 20782 USA.
10
Albert Einstein College of Medicine, Montefiore Heart and Vascular Center, 111 East 210th Street, Bronx, NY 10467-2401 USA.
11
Program for Health Data and Standardized Methods, Center for Health Data Analytics | eHealth, Quality & Analytics Division, RTI International | 307 Waverley Oaks Road, Suite 101, Waltham, MA 02452 USA.
12
Rollins School of Public Health, Emory University, 1518 Clifton Rd Rm 4005, Atlanta, GA 30322 USA.
13
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8856 USA.

Abstract

Persons of Hispanic/Latino descent may represent different ancestries, ethnic and cultural groups and countries of birth. In the U.S., the Hispanic/Latino population is projected to constitute 29% of the population by 2060. A personalized approach focusing on individual variability in genetics, environment, lifestyle and socioeconomic determinants of health may advance the understanding of some of the major factors contributing to the health disparities experienced by Hispanics/Latinos and other groups in the U.S., thus leading to new strategies that improve health care outcomes. However, there are major gaps in our current knowledge about how personalized medicine can shape health outcomes among Hispanics/Latinos and address the potential factors that may explain the observed differences within this heterogeneous group, and between this group and other U.S. demographic groups. For that purpose, the National Heart, Lung, and Blood Institute (NHLBI), in collaboration with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the Food and Drug Administration (FDA), held a workshop in which experts discussed (1) potential approaches to study medical treatments and health outcomes among Hispanics/Latinos and garner the necessary evidence to fill gaps of efficacy, effectiveness and safety of therapies for heart, lung, blood and sleep (HLBS) disorders and conditions--and their risk factors; (2) research opportunities related to personalized medicine to improve knowledge and develop effective interventions to reduce health disparities among Hispanics/Latinos in the U.S.; and (3) the incorporation of expanded sociocultural and socioeconomic data collection and genetic/genomic/epigenetic information of Hispanic/Latino patients into their clinical assessments, to account for individual variability in ancestry; physiology or disease risk; culture; environment; lifestyle; and socioeconomic determinants of health. The experts also provided recommendations on: sources of Hispanic/Latino health data and strategies to enhance its collection; policy; genetics, genomics and epigenetics research; and integrating Hispanic/Latino health research within clinical settings.

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