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Int J Mol Sci. 2017 Nov 17;18(11). pii: E2439. doi: 10.3390/ijms18112439.

Changes of Cerebral and/or Peripheral Adenosine A₁ Receptor and IGF-I Concentrations under Extended Sleep Duration in Rats.

Author information

1
Institut de Recherche Biomédicale des Armées (IRBA), Département Neurosciences et Contraintes Opérationnelles, 91223 Brétigny sur Orge, France. mounirchennaoui@gmail.com.
2
Equipe d'accueil EA7330 VIFASOM, Université Paris Descartes, Hôtel Dieu, (Vigilance Fatigue et Sommeil), 75004 Paris, France. mounirchennaoui@gmail.com.
3
Institut de Recherche Biomédicale des Armées (IRBA), Département Neurosciences et Contraintes Opérationnelles, 91223 Brétigny sur Orge, France. pierrick.arnal@gmail.com.
4
Equipe d'accueil EA7330 VIFASOM, Université Paris Descartes, Hôtel Dieu, (Vigilance Fatigue et Sommeil), 75004 Paris, France. pierrick.arnal@gmail.com.
5
Laboratoire de Physiologie de l'Exercice, Université de Lyon, 42000 Saint Etienne, France. pierrick.arnal@gmail.com.
6
Institut de Recherche Biomédicale des Armées (IRBA), Département Neurosciences et Contraintes Opérationnelles, 91223 Brétigny sur Orge, France. dorey.rodolphe@gmail.com.
7
Equipe d'accueil EA7330 VIFASOM, Université Paris Descartes, Hôtel Dieu, (Vigilance Fatigue et Sommeil), 75004 Paris, France. dorey.rodolphe@gmail.com.
8
Institut de Recherche Biomédicale des Armées (IRBA), Département Neurosciences et Contraintes Opérationnelles, 91223 Brétigny sur Orge, France. fabien.sauvet@gmail.com.
9
Equipe d'accueil EA7330 VIFASOM, Université Paris Descartes, Hôtel Dieu, (Vigilance Fatigue et Sommeil), 75004 Paris, France. fabien.sauvet@gmail.com.
10
Institut de Recherche Biomédicale des Armées (IRBA), Département Neurosciences et Contraintes Opérationnelles, 91223 Brétigny sur Orge, France. ciret.sylvain@gmail.com.
11
ESPCI ParisTech, Laboratoire Plasticité du Cerveau, 75005 Paris, France. thierry.gallopin@espci.fr.
12
Equipe d'accueil EA7330 VIFASOM, Université Paris Descartes, Hôtel Dieu, (Vigilance Fatigue et Sommeil), 75004 Paris, France. damien.leger@htd.aphp.fr.
13
Centre du Sommeil et de la Vigilance, Hôtel Dieu, APHP, 75004 Paris, France. damien.leger@htd.aphp.fr.
14
Institut de Recherche Biomédicale des Armées (IRBA), Département Neurosciences et Contraintes Opérationnelles, 91223 Brétigny sur Orge, France. catherine.drogou@gmail.com.
15
Equipe d'accueil EA7330 VIFASOM, Université Paris Descartes, Hôtel Dieu, (Vigilance Fatigue et Sommeil), 75004 Paris, France. catherine.drogou@gmail.com.
16
Institut de Recherche Biomédicale des Armées (IRBA), Département Neurosciences et Contraintes Opérationnelles, 91223 Brétigny sur Orge, France. dangomez51@gmail.com.
17
Equipe d'accueil EA7330 VIFASOM, Université Paris Descartes, Hôtel Dieu, (Vigilance Fatigue et Sommeil), 75004 Paris, France. dangomez51@gmail.com.

Abstract

Extended sleep improves sustained attention and reduces sleep pressure in humans. Downregulation of adenosine A₁ receptor (A₁R) and modulation of the neurotrophic factor insulin growth factor-1 (IGF-I) in brain structures controlling attentional capacities could be involved. In the frontal cortex and hippocampus of rats, we measured adenosine A₁R and IGF-I protein concentrations after photoperiod-induced sleep extension. Two groups of twelve rats were adapted over 14 days to a habitual (CON) 12:12 light-dark (LD) schedule and an extended (EXT) 16:8 LD schedule. IGF-I content was also measured in plasma, liver, and skeletal muscle. In EXT, compared to CON rats, A₁R content in the frontal cortex was significantly lower (p < 0.05), while IGF-I content was higher (p < 0.001), and no significant change was observed in the hippocampus. IGF-I content in plasma and muscle was higher (p < 0.001 and p < 0.01), while it was lower in liver (p < 0.001). The absolute weight and weight gain were higher in EXT rats (p < 0.01). These data suggest that 14 days under a 16:8 LD photoperiod respectively down- and upregulated cortical A₁R and IGF-I levels. This photoperiod induced an anabolic profile with increased weight gain and circulating and muscular IGF-I levels. An extension of sleep duration might favor cerebral and peripheral anabolism, which may help attentional and physical capacities.

KEYWORDS:

A1 receptor; IGF-I; hormones; peripheral and brain tissues; sleep extension

PMID:
29149028
PMCID:
PMC5713406
DOI:
10.3390/ijms18112439
[Indexed for MEDLINE]
Free PMC Article

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