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Cell Biol Int. 2018 Mar;42(3):365-372. doi: 10.1002/cbin.10909. Epub 2017 Nov 22.

MCP2 activates NF-κB signaling pathway promoting the migration and invasion of ESCC cells.

Zhou J1,2, Zheng S2,3, Liu T2,3, Liu Q2,3, Chen Y1,2, Tan D1,2, Ma R1,2, Lu X1,2.

Author information

1
Tumor Hospital Affiliated to Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi, P.R. China.
2
State Key Laboratory of Pathogenesis, Prevention, Treatment of Central Asian High Incidence Diseases, Xinjiang Uygur Autonomous Region, Urumqi, P.R. China.
3
Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi, P.R. China.

Abstract

MCP2, aliased CCL8, has been suggested to be implicated in the metastasis of cancer cells; however, no direct evidence has been established in esophageal squamous cell carcinoma (ESCC). In our present study, to investigate the role MCP2 played in the metastasis of ESCC cells; in vitro cell co-culture system was established. Wound-healing and Transwell assays were used to evaluate the migratory and invasive variation of ESCC cells before and after treatment with recombinant human MCP2. It was shown that MCP2 was able to activate the NF-κB signaling pathway inducing the epithelial-mesenchymal transition (EMT) and promoting the migration and invasion of ESCC cells in vitro. Our study provides an alternative working mechanism for M2 macrophage mediated the metastasis in tumor microenvironment in ESCC.

KEYWORDS:

ESCC; M2 macrophage; MCP2; NF-κB; invasion; migration

PMID:
29148603
DOI:
10.1002/cbin.10909
[Indexed for MEDLINE]

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