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Arch Dermatol Res. 2018 Apr;310(3):181-185. doi: 10.1007/s00403-017-1795-3. Epub 2017 Nov 17.

Skin barrier and microbiome in acne.

Author information

1
Federal University of São Paulo (Escola Paulista de Medicina-Universidade Federal de São Paulo), Rua Eugenio Bettarello 55 ap 134B, São Paulo, SP, Brazil. marcoderm@hotmail.com.
2
Federal University of São Paulo (Escola Paulista de Medicina-Universidade Federal de São Paulo), Rua Eugenio Bettarello 55 ap 134B, São Paulo, SP, Brazil.

Abstract

Acne is an immune-mediated chronic inflammatory disease. Although several factors are involved in its pathophysiology, this process is not completely understood. Androgen hormone activity increases sebum production inside the pilosebaceous follicle, adjusting the environment for the development of Propionibacterium acnes which triggers inflammation. Knowing how others factors such as the skin barrier and microbiome are involved in acne, can help in understanding more about the disease and may help to conduct a better treatment.

KEYWORDS:

Acne; Microbiome; Microbiota; Skin barrier

PMID:
29147769
DOI:
10.1007/s00403-017-1795-3
[Indexed for MEDLINE]

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