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Clin J Am Soc Nephrol. 2017 Dec 7;12(12):1974-1983. doi: 10.2215/CJN.01280217. Epub 2017 Nov 16.

Phenotypic Spectrum of Children with Nephronophthisis and Related Ciliopathies.

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Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.



Genetic heterogeneity and phenotypic variability are major challenges in familial nephronophthisis and related ciliopathies. To date, mutations in 20 different genes (NPHP1 to -20) have been identified causing either isolated kidney disease or complex multiorgan disorders. In this study, we provide a comprehensive and detailed characterization of 152 children with a special focus on extrarenal organ involvement and the long-term development of ESRD.


We established an online-based registry ( to assess the clinical course of patients with nephronophthisis and related ciliopathies on a yearly base. Cross-sectional and longitudinal data were collected. Mean observation time was 7.5±6.1 years.


In total, 51% of the children presented with isolated nephronophthisis, whereas the other 49% exhibited related ciliopathies. Monogenetic defects were identified in 97 of 152 patients, 89 affecting NPHP genes. Eight patients carried mutations in other genes related to cystic kidney diseases. A homozygous NPHP1 deletion was, by far, the most frequent genetic defect (n=60). We observed a high prevalence of extrarenal manifestations (23% [14 of 60] for the NPHP1 group and 66% [61 of 92] for children without NPHP1). A homozygous NPHP1 deletion not only led to juvenile nephronophthisis but also was able to present as a predominantly neurologic phenotype. However, irrespective of the initial clinical presentation, the kidney function of all patients carrying NPHP1 mutations declined rapidly between the ages of 8 and 16 years, with ESRD at a mean age of 11.4±2.4 years. In contrast within the non-NPHP1 group, there was no uniform pattern regarding the development of ESRD comprising patients with early onset and others preserving normal kidney function until adulthood.


Mutations in NPHP genes cause a wide range of ciliopathies with multiorgan involvement and different clinical outcomes.


Adolescent; Bardet-Biedl syndrome; COACH syndrome; Ciliopathies; Congenital oculomotor apraxia; Cross-Sectional Studies; Genetic Heterogeneity; Homozygote; Joubert-like syndromes; Kidney Diseases, Cystic; Kidney Failure, Chronic; Mainzer-Saldino syndrome; Mutation; NEPHREG registry; Nephronophthisis (NPH); Nephronophthisis related ciliopathy; Nephronophthisis, familial juvenile; Prevalence; Registries; Senior-Løken syndrome

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