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J Am Coll Cardiol. 2017 Nov 14;70(20):2552-2565. doi: 10.1016/j.jacc.2017.09.1095.

Cardiovascular Complications of Cancer Therapy: Best Practices in Diagnosis, Prevention, and Management: Part 2.

Author information

1
Center for Precision Medicine, Department of Medicine, University of Missouri, Columbia, Missouri.
2
Division of Cardiology, Rush University Medical Center, Chicago, Illinois.
3
Division of Cardiology, Virginia Common Wealth University, Richmond, Virginia.
4
Department of Cardiology, University of Texas, MD Anderson Cancer Center, Houston, Texas.
5
Center for Precision Medicine, Department of Medicine, University of Missouri, Columbia, Missouri. Electronic address: yehet@health.missouri.edu.

Abstract

In this second part of a 2-part review, we will review cancer or cancer therapy-associated systemic and pulmonary hypertension, QT prolongation, arrhythmias, pericardial disease, and radiation-induced cardiotoxicity. This review is based on a MEDLINE search of published data, published clinical guidelines, and best practices in major cancer centers. Newly developed targeted therapy can exert off-target effects causing hypertension, thromboembolism, QT prolongation, and atrial fibrillation. Radiation therapy often accelerates atherosclerosis. Furthermore, radiation can damage the heart valves, the conduction system, and pericardium, which may take years to manifest clinically. Management of pericardial disease in cancer patients also posed clinical challenges. This review highlights the unique opportunity of caring for cancer patients with heart problems caused by cancer or cancer therapy. It is an invitation to action for cardiologists to become familiar with this emerging subspecialty.

KEYWORDS:

cancer therapy; cardiovascular complication; hypertension; radiation therapy; thromboembolism

PMID:
29145955
PMCID:
PMC5825188
DOI:
10.1016/j.jacc.2017.09.1095
[Indexed for MEDLINE]
Free PMC Article

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