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Toxicol Sci. 2018 Feb 1;161(2):443-453. doi: 10.1093/toxsci/kfx226.

Editor's Highlight: Variation in Methylmercury Metabolism and Elimination Status in Humans Following Fish Consumption.

Author information

1
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642.
2
Trace Element Analysis Laboratory, Dartmouth College, Hanover, New Hampshire 03755.
3
Department of Microbiology and Immunology.
4
Department of Biostatistics and Computational Biology.
5
Eastman Institute for Oral Health.
6
Department of Pharmacology and Physiology.
7
Department of Pediatrics.
8
Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642.

Abstract

Evaluating the potential for methylmercury (MeHg) toxicity relies on accurately predicting the mercury (Hg) body burden that results from eating fish. Hg body burden is directly determined by the slow elimination kinetics of MeHg in the human body (kel = 0.014 days-1 or t1/2 =50 days). Existing studies on MeHg half-life in humans demonstrate a wide range values (t1/2 = 30 to >150 days) and has lead to uncertainty in the derivation of a regulatory standard for acceptable daily oral intake. The causes of variation in MeHg toxicokinetics in humans remain little explored. Here we characterize variation in human MeHg metabolism and elimination rate (kel) in 37 adult volunteers who consumed 3 fish meals. We determined MeHg elimination rates via longitudinal Hg analysis in single hairs using laser ablation inductively coupled plasma mass spectrometry. We also measured MeHg metabolism (biotransformation) via speciation of fecal Hg. We find an average kel = 0.0157 days-1 (t1/2 = 44 days) amongst a more than 2-fold variation in kel across the cohort (0.0248-0.0112 days-1; t1/2 = 28-62 days). Although MeHg biotransformation varied widely between individuals, it showed a positive association with elimination rates across the cohort. A more than 2-fold change in kel over a period of 2 years was seen in some individuals. In 2 individuals, who received antibiotic for unrelated health issues, elimination rate was seen to slow significantly. Associations of kel with age, body mass index, gender, and fish eating habits were not observed. We establish that a measure of methylmercury metabolism and eliminaiton status (MerMES) can reduce uncertainty in determining an individual's MeHg toxicokinetics subsequent to eating fish.

KEYWORDS:

biotransformation; elimination; half-life; laser ablation ICP-MS; metabolism; methylmercury; toxicokinetics

PMID:
29145616
PMCID:
PMC5837402
DOI:
10.1093/toxsci/kfx226
[Indexed for MEDLINE]
Free PMC Article

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