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Gut Microbes. 2018;9(3):189-201. doi: 10.1080/19490976.2017.1406584. Epub 2018 Mar 13.

Low dietary fiber intake increases Collinsella abundance in the gut microbiota of overweight and obese pregnant women.

Author information

1
a UQ Centre for Clinical Research, The University of Queensland , Brisbane , Australia.
2
b Faculty of Medicine, The University of Queensland , Brisbane , Australia.
3
c Obstetric Medicine, Royal Brisbane and Women's Hospital , Brisbane , Australia.
4
d Mater Health Services, Nutrition and Dietetics, Mater Hospital , Brisbane , Australia.
5
g Mater Research Institute -University of Queensland , Brisbane , Australia.
6
e Diamantina Institute, The University of Queensland , Brisbane , Australia.
7
f School of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane , Australia.

Abstract

The gut microbiota contributes to the regulation of glucose metabolism in pregnancy. Abundance of the genus Collinsella is positively correlated with circulating insulin; however, it is unclear what determines Collinsella abundance. This study aims to validate the correlation between Collinsella and insulin and to elucidate if macronutrient intake alters Collinsella abundance and gut microbiota composition. Gut microbiota profiles were assessed by 16S rRNA sequencing in 57 overweight and 73 obese pregnant women from the SPRING (Study of PRobiotics IN Gestational diabetes) trial at 16 weeks gestation and correlated with metabolic hormone levels and macronutrient intake. Gut microbiota composition in the top and bottom 10% of dietary fiber intake was evaluated through network analysis. Collinsella abundance correlated positively with circulating insulin (rho = 0.30, p = 0.0006), independent of maternal BMI, but negatively with dietary fiber intake (rho = -0.20, p = 0.025) in this cohort. Low dietary fiber intake was associated with a gut microbiota favoring lactate fermentation while high fiber intake promotes short-chain fatty acid-producing bacteria. Low dietary fiber may enable overgrowth of Collinsella and alter the overall fermentation pattern in gut microbiota. This suggests that dietary choices during pregnancy can modify the nutritional ecology of the gut microbiota, with potential deleterious effects on the metabolic and inflammatory health of the host.

TRIAL REGISTRATION:

ANZCTR 12611001208998, registered 23/11/2011.

KEYWORDS:

Collinsella; Fiber and Obesity; Insulin; Microbiota; Pregnancy

PMID:
29144833
PMCID:
PMC6219589
DOI:
10.1080/19490976.2017.1406584
[Indexed for MEDLINE]
Free PMC Article

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