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Nat Immunol. 2017 Nov 16;18(12):1288-1298. doi: 10.1038/ni.3858.

Novel mechanisms and functions of complement.

Author information

1
Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
2
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
3
Division of Biodiagnostic Sciences and Technologies, INRASTES, National Center for Scientific Research 'Demokritos', Aghia Paraskevi, Athens, Greece.
4
Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

Abstract

Progress at the beginning of the 21st century transformed the perception of complement from that of a blood-based antimicrobial system to that of a global regulator of immunity and tissue homeostasis. More recent years have witnessed remarkable advances in structure-function insights and understanding of the mechanisms and locations of complement activation, which have added new layers of complexity to the biology of complement. This complexity is readily reflected by the multifaceted and contextual involvement of complement-driven networks in a wide range of inflammatory and neurodegenerative disorders and cancer. This Review provides an updated view of new and previously unanticipated functions of complement and how these affect immunity and disease pathogenesis.

PMID:
29144501
PMCID:
PMC5706779
DOI:
10.1038/ni.3858
[Indexed for MEDLINE]
Free PMC Article

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