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J Diabetes. 2018 May;10(5):408-418. doi: 10.1111/1753-0407.12625. Epub 2018 Jan 18.

Association between smoking and glycemic control in diabetic patients: Results from the Risk Evaluation of cAncers in Chinese diabeTic Individuals: A lONgitudinal (REACTION) study.

Author information

1
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
2
Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China.
3
Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.
4
Chinese People's Liberation Army General Hospital, Beijing, China.
5
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
6
Affiliated Hospital of Guiyang Medical College, Guiyang, China.
7
Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
8
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
9
The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
10
The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
11
Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
12
The Affiliated Hospital of Southwest Medical University, Luzhou, China.
13
Karamay Municipal People's Hospital, Xinjiang, China.
14
The First Hospital of Jilin University, Changchun, China.
15
The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
16
The First Hospital of Lanzhou University, Lanzhou, China.
17
Jiangxi People's Hospital, Nanchang, China.
18
Dalian Municipal Central Hospital, Dalian, China.
19
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
20
The First Affiliated Hospital of Anhui Medical University, Hefei, China.
21
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
22
The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
23
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
24
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
25
Qilu Hospital of Shandong University, Jinan, China.
26
Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Abstract

BACKGROUND:

A number of primary studies suggested that active smoking could be independently associated with incident diabetes. However less is known about the effect of active smoking and smoking cessation on glycemic control in patients with diabetes. The aim of this study was to evaluate the associations of active smoking and smoking cessation with glycemic control in diabetic patients.

METHODS:

The present was a cross-sectional study of 10 551 men and 15 297 women with diabetes from the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study. Risk factors for glycemic control and the association of active smoking with glycemic control were evaluated using logistic regression models. Poor glycemic control was defined as HbA1c ≥7.0%.

RESULTS:

Current smokers have an increased risk of poor glycemic control, and the multivariable-adjusted odds ratio (OR) and 95% confidence intervals (CI) of HbA1c ≥7.0% with current smoking were 1.49 (1.35-1.66) in men and 1.56 (1.13-2.15) in women. Further analysis demonstrated a dose-dependent relationship between active smoking and the risk of poor glycemic control in men. Former smokers who quit smoking for <10 years remained at increased risk of poor glycemic control, with the risk leveling off after 10 years of smoking cessation compared with non-smokers, but risk in former smokers was significantly lower than that in current smokers.

CONCLUSIONS:

Active smoking is a modifiable risk factor for poor glycemic control in Chinese diabetic patients.

KEYWORDS:

diabetes; glycemic control; smoking; 吸烟; 糖尿病; 血糖控制

PMID:
29144059
DOI:
10.1111/1753-0407.12625
[Indexed for MEDLINE]

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