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Mol Nutr Food Res. 2018 Feb;62(4). doi: 10.1002/mnfr.201700537. Epub 2018 Jan 22.

Response of Red Blood Cell Folate to Supplementation in Nonpregnant Women is Predictable: A Proposal for Personalized Supplementation.

Author information

1
Department of Clinical Chemistry, Saarland University Hospital, Homburg, Germany.
2
Aarhus Institute of Advanced Studies, University of Aarhus, Aarhus C, Denmark.
3
BioTeSys GmbH, Esslingen, Germany.
4
Department of Mathematics, Natural and Economic Sciences, University of Applied Sciences Ulm, Ulm, Germany.
5
Octet Research Inc., Boston, MA, USA.
6
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
7
Department of Nutrition and Food Science, Rheinische Friedrich-Wilhelms University, Bonn, Germany.

Abstract

SCOPE:

We modeled red blood cell (RBC)-folate response to supplementation and developed personalized folate supplementation concepts.

METHODS AND RESULTS:

The changes of RBC-folate were modeled in a time- (4 or 8 weeks) and dose- (400 or 800 μg d-1 folate) dependent manner. Post-supplementation RBC-folate levels were predicted from folate-loading capacities (= measured RBC-folate - [baseline RBC-folate × RBC-survival]). The prediction equations were validated in 119 participants. The median increase of RBC-folate was higher in the 800 μg d-1 than in the 400 μg d-1 group (275 vs 169 nmol L-1 after 4 weeks, and 551 vs 346 nmol L-1 after 8 weeks). Medians (interquartile range) of RBC-folate loading were (4 weeks: 299 (160) vs 409 (237) nmol L-1 ) and (8 weeks: 630 (134) versus 795 (187) nmol L-1 ) in the 400 and 800 μg d-1 group, respectively. The individual measured and predicted RBC-folate values (after 4 weeks/400 μg d-1 = 25 + 1.27 × baseline RBC-folate) and (after 4 weeks/800 μg d-1 = 65 + 1.41 × baseline RBC-folate) did not differ significantly. The measured and predicted concentrations showed high agreement in the validation cohort.

CONCLUSIONS:

The models can guide nutritional recommendations in women when baseline RBC-folate concentrations are measured and the time to pregnancy between 4 and 8 weeks.

KEYWORDS:

RBC-folate; birth defects; folate requirement; pregnancy; supplementation

PMID:
29143484
PMCID:
PMC5838518
DOI:
10.1002/mnfr.201700537
[Indexed for MEDLINE]
Free PMC Article

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