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Transgend Health. 2017 Nov 1;2(1):195-201. doi: 10.1089/trgh.2017.0021. eCollection 2017.

Induction and Maintenance of Amenorrhea in Transmasculine and Nonbinary Adolescents.

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Department of Medicine, Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts.


The treatment of persistent uterine bleeding in those patients who identify as transmasculine or nonbinary is often straightforward, but can be difficult in a subset of patients. This article reviews the physiology of the normal menstrual cycle and the hormonal influences on the endometrium, and then explores options for the treatment of persistent bleeding for people both already on testosterone and for those who are either not ready for or who do not desire testosterone.


endometrium; gonadotropin releasing hormone analogs; progestins; secondary amenorrhea; testosterone; uterine bleeding

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