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Br J Ophthalmol. 2018 Aug;102(8):1028-1035. doi: 10.1136/bjophthalmol-2017-311328. Epub 2017 Nov 15.

Adaptive optics imaging of inherited retinal diseases.

Author information

1
UCL Institute of Ophthalmology, University College London, London, UK.
2
Moorfields Eye Hospital NHS Foundation Trust, London, UK.
3
Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
4
Department of Ophthalmology, Stanford University, Palo Alto, California, USA.

Abstract

Adaptive optics (AO) ophthalmoscopy allows for non-invasive retinal phenotyping on a microscopic scale, thereby helping to improve our understanding of retinal diseases. An increasing number of natural history studies and ongoing/planned interventional clinical trials exploit AO ophthalmoscopy both for participant selection, stratification and monitoring treatment safety and efficacy. In this review, we briefly discuss the evolution of AO ophthalmoscopy, recent developments and its application to a broad range of inherited retinal diseases, including Stargardt disease, retinitis pigmentosa and achromatopsia. Finally, we describe the impact of this in vivo microscopic imaging on our understanding of disease pathogenesis, clinical trial design and outcome metrics, while recognising the limitation of the small cohorts reported to date.

KEYWORDS:

genetics; imaging; retina; vision

PMID:
29141905
PMCID:
PMC6059037
DOI:
10.1136/bjophthalmol-2017-311328
[Indexed for MEDLINE]
Free PMC Article

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