Format

Send to

Choose Destination
Am J Trop Med Hyg. 2017 Dec;97(6):1686-1690. doi: 10.4269/ajtmh.16-0529. Epub 2017 Oct 26.

Clinical Isolation of Anaplasma phagocytophilum in South Korea.

Author information

1
Division of Zoonoses, Center for Immunology and Pathology, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Chungcheongbuk-do, Republic of Korea.
2
Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.
3
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
4
Division of Biosafety Evaluation and Control, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Chungcheongbuk-do, Republic of Korea.
5
Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Abstract

We report the first isolation of Anaplasma phagocytophilum in South Korea. A 61-year-old woman presented with a 6-day history of fever, headache, and myalgia. Initial investigation showed neutropenia and thrombocytopenia. We diagnosed human granulocytic anaplasmosis by microscopic examination and serologic testing. The patient recovered fully without antibiotic therapy. The isolate was obtained from the patient's blood by cell culture and mouse inoculation. Its identity was confirmed by an immunofluorescence assay, sequencing of the 16S rRNA gene, msp2 (p44), and ankA genes, and staining and electron microscopy of morulae of A. phagocytophilum in cultured human promyelocytic leukemia HL-60 cells.

PMID:
29141715
PMCID:
PMC5805025
DOI:
10.4269/ajtmh.16-0529
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Ingenta plc Icon for PubMed Central
Loading ...
Support Center