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J Infect Dis. 2018 Jan 17;217(3):353-357. doi: 10.1093/infdis/jix587.

DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users.

Author information

1
Department of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands.
2
Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands.
3
Department of Internal Medicine, Amsterdam, The Netherlands.
4
Department of Microbiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
5
Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine, and AIDS, Center for Infection and Immunity Amsterdam, Amsterdam, The Netherlands.
6
Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands.
7
Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, UK.

Abstract

We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs) -139, -871, and -939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.

KEYWORDS:

DC-SIGN; Hepatitis C virus; lectin; sexual transmission; single nucleotide polymorphism

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