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Biomed Res Int. 2017;2017:6705363. doi: 10.1155/2017/6705363. Epub 2017 Sep 12.

The Effect of Granulocyte Colony-Stimulating Factor on the Progression of Atherosclerosis in Animal Models: A Meta-Analysis.

Liu M1,2, Liu K3,4, Chen D1,2, Chen H1,2, Sun K1,2, Ju X1,2, Lan J1,2, Zhou Y1,2, Wang W5, Pang L1,2.

Author information

1
Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Ministry of Education, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
2
Department of Pathology, The First Affiliated Hospital to Shihezi University School of Medicine, Shihezi, Xinjiang, China.
3
Department of Cardiology, The First Affiliated Hospital to Shihezi University School of Medicine, 45 North 3rd Road, Shihezi, Xinjiang, China.
4
Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, China.
5
Department of Orthopaedics, Shihezi University School of Medicine, 45 North 3rd Road, Shihezi, Xinjiang, China.

Abstract

Background:

Atherosclerosis is a common inflammatory disease. Stem cell and endothelial progenitor cell treatments can improve cardiac function after myocardial infarction. Granulocyte colony-stimulating factor (G-CSF) is a mobilisation agent, mobilising stem cells from the bone marrow to circulation in the blood. G-CSF may constitute a treatment of atherosclerosis. We have conducted meta-analysis to evaluate the current evidence for the effect of G-CSF on the progression of atherosclerosis in animal models and to provide reference for preclinical experiments and future human clinical trials of atherosclerosis treatment.

Methods:

We searched several databases and conducted a meta-analysis across seven articles using a random-effect model. All statistical analyses were performed using Review Manager Version 5.2 and Stata 12.0.

Results:

We found that G-CSF therapy was associated with reduced atherosclerotic lesion area (weighted mean difference (WMD): 7.29%; 95% confidence interval (CI): 2.06-12.52%; P = 0.006). No significant differences in total serum cholesterol (P = 0.54) and triglyceride levels (P = 0.95) were noted in G-CSF treatment groups compared with controls. Multivariable metaregression analysis revealed that the animal type (rabbit, P = 0.022) and frequency of G-CSF administration (>20, P = 0.007) impacted the atherosclerotic lesion area changes.

Conclusion:

The meta-analysis suggested that G-CSF treatment might inhibit the progression of atherosclerosis in animal models.

PMID:
29138752
PMCID:
PMC5613364
DOI:
10.1155/2017/6705363
[Indexed for MEDLINE]
Free PMC Article

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