Format

Send to

Choose Destination
Int J Parasitol. 2018 Apr;48(5):387-393. doi: 10.1016/j.ijpara.2017.08.008. Epub 2017 Nov 12.

Clearance of schistosome parasites by resistant genotypes at a single genomic region in Biomphalaria glabrata snails involves cellular components of the hemolymph.

Author information

1
Department of Integrative Biology, College of Science, Oregon State University, Corvallis, OR, USA. Electronic address: euanroallan@gmail.com.
2
Université Perpignan Via Domitia, Interactions Hôtes Pathogènes Environnements UMR 5244, CNRS, IFREMER, Univ. Montpellier, F-66860 Perpignan, France.
3
Department of Biomedical Sciences, Oregon State University, Corvallis, OR, USA.
4
Department of Integrative Biology, College of Science, Oregon State University, Corvallis, OR, USA.

Abstract

Schistosomiasis is one of the most detrimental neglected tropical diseases. Controlling the spread of this parasitic illness requires effective sanitation, access to chemotherapeutic drugs, and control over populations of the freshwater snails, such as Biomphalaria glabrata, that are essential intermediate hosts for schistosomes. Effectively controlling this disease, while minimising ecological implications of such control, will require an extensive understanding of the immunological interactions between schistosomes and their molluscan intermediate hosts. Here we histologically characterise the clearance of schistosome larvae by snails that exhibit allelic variation at a single genomic region, the Guadeloupe resistance complex. We show that snails with a resistant Guadeloupe resistance complex genotype clear schistosomes within the first 24-48 h, and that this resistance can be transferred to susceptible snails via whole hemolymph but not cell-free plasma. These findings imply that Guadeloupe resistance complex-coded proteins help to coordinate hemocyte-mediated immune responses to schistosome infections in Guadeloupean snails.

KEYWORDS:

Biomphalaria glabrata; Hemocyte; Hemolymph transfer; Histology; Plasma transfer; Resistance; Schistosomiasis

PMID:
29137971
PMCID:
PMC5893386
DOI:
10.1016/j.ijpara.2017.08.008
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center