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Proc Nutr Soc. 2017 Nov;76(4):619-627. doi: 10.1017/S0029665117003949.

Combining traditional dietary assessment methods with novel metabolomics techniques: present efforts by the Food Biomarker Alliance.

Author information

1
Division of Human Nutrition,Wageningen University,PO Box 17,6700 AA Wageningen,The Netherlands.
2
UCD School of Agriculture and Food Science,UCD, Dublin,Ireland.
3
Department of Nutrition,Institute of Basic Medical Sciences,Faculty of Medicine,University of Oslo,Oslo,Norway.
4
National Institute for Public Health and the Environment,Bilthoven,The Netherlands.
5
INRA,UMR 1019, Human Nutrition Unit,Université Clermont Auvergne,Clermont-Ferrand,France.
6
Department of Nutrition,Exercise and Sports,University of Copenhagen,Copenhagen,Denmark.
7
Nutrigenomics Research Group,UCD Institute of Food and Health,School of Public Health,Physiotherapy and Sports Science,Belfield,Dublin 4,Ireland.
8
Biomarkers and Nutrimetabolomic Laboratory,Department of Nutrition,Food Sciences and Gastronomy, XaRTA, INSA,Faculty of Pharmacy and Food Sciences,University of Barcelona,Barcelona,Spain.
9
Department of Internal Medicine,University Medical Center Groningen, University of Groningen,Groningen,The Netherlands.
10
TNO,Netherlands Organisation for Applied Scientific Research,Zeist,The Netherlands.
11
Department of Agricultural and Food Science,University of Bologna,Italy.
12
Faculty of Pharmaceutical Sciences, Department of Bioanalysis,Ghent University,Ghent,Belgium.
13
Vitas Ltd - Analytical Services,Oslo,Norway.
14
University of Eastern Finland,Institute of Public Health and Clinical Nutrition,Clinical Nutrition,Kuopio,Finland.
15
Max Rubner-Institut, Bundesforschungsinstitut für Ernährung und Lebensmittel,Karlsruhe,Germany.
16
Department of Biology and Biological Engineering, Food and Nutrition Science,Chalmers University of Technology,Gothenburg,Sweden.
17
Institute of Epidemiology II,Helmholtz Centre Munich,Neuherberg,Germany.
18
Fondazione Edmund Mach,Department of Food Quality and Nutrition,Research and Innovation Centre,San Michele all'Adige,Italy.
19
Department of Human Biology,NUTRIM School of Nutrition and Translational Research in Metabolism,Maastricht University Medical Center,Maastricht,The Netherlands.
20
Consiglio per la Ricerca in Agricoltura e l'analisi dell'economia agraria - Food and Nutrition Research Center,Roma,Italy.
21
ZIEL Institute for Food and Health,Core Facility Human Studies,Nutritional Medicine,Technical University of Munich,Freising,Germany.
22
Division of Food,Disease Prevention and Toxicology,National Food Institute,Technical University of Denmark,Kongens Lyngby,Denmark.
23
Agroscope,Institute for Food Sciences IFS,Bern,Switzerland.
24
Departments of Biological Sciences and Computing Science,University of Alberta,Edmonton,Canada.
25
International Agency for Research on Cancer,Nutrition and Metabolism Section,Lyon,France.

Abstract

FFQ, food diaries and 24 h recall methods represent the most commonly used dietary assessment tools in human studies on nutrition and health, but food intake biomarkers are assumed to provide a more objective reflection of intake. Unfortunately, very few of these biomarkers are sufficiently validated. This review provides an overview of food intake biomarker research and highlights present research efforts of the Joint Programming Initiative 'A Healthy Diet for a Healthy Life' (JPI-HDHL) Food Biomarkers Alliance (FoodBAll). In order to identify novel food intake biomarkers, the focus is on new food metabolomics techniques that allow the quantification of up to thousands of metabolites simultaneously, which may be applied in intervention and observational studies. As biomarkers are often influenced by various other factors than the food under investigation, FoodBAll developed a food intake biomarker quality and validity score aiming to assist the systematic evaluation of novel biomarkers. Moreover, to evaluate the applicability of nutritional biomarkers, studies are presently also focusing on associations between food intake biomarkers and diet-related disease risk. In order to be successful in these metabolomics studies, knowledge about available electronic metabolomics resources is necessary and further developments of these resources are essential. Ultimately, present efforts in this research area aim to advance quality control of traditional dietary assessment methods, advance compliance evaluation in nutritional intervention studies, and increase the significance of observational studies by investigating associations between nutrition and health.

KEYWORDS:

Dietary assessment; Food intake biomarkers; Food metabolome; Metabolomics

PMID:
29137687
DOI:
10.1017/S0029665117003949
[Indexed for MEDLINE]

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