Format

Send to

Choose Destination
Oncotarget. 2017 Aug 24;8(48):84237-84247. doi: 10.18632/oncotarget.20494. eCollection 2017 Oct 13.

Caspase-3 expression in tumorigenesis and prognosis of buccal mucosa squamous cell carcinoma.

Author information

1
Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
2
National Yang-Ming University School of Medicine, Taipei, Taiwan.
3
Department of Stomatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
4
Department of Dental Technology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan.
5
Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
6
Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
7
Department of Pathology, China Medical University Hospital, Taichung, Taiwan.
8
Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
9
Department of Optometry, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan.
#
Contributed equally

Abstract

Buccal mucosa squamous cell carcinoma (BMSCC) is the most common oral cancer in Southeast Asia. Caspase-3, a key molecule in regulating apoptosis, promotes the malignancy of various cancers. However, its role in BMSCC is unknown. Herein, we evaluated the association of caspase-3 expression with tumorigenesis and prognosis in BMSCC patients. Immunohistochemical staining indicated that the expression levels of cleaved caspase-3 (p<0.001) and caspase-3 (p<0.001) in 185 BMSCC tissues were significantly higher compared to those in the tumor adjacent normal tissues. Moreover, the high expression of caspase-3 was associated with poor pathological outcomes [advanced pathological stage (p=0.029) and larger tumor size (p=0.002)] and poor disease-free survival in patients receiving postoperative radiotherapy (p=0.030). Moreover, the low co-expression of cleaved caspase-3 and caspase-3 was associated with better disease-specific survival in patients with early pathological stage (I + II, p=0.018) or without lymph node invasion (p=0.043) compared to the positive/high expression of either or both cleaved caspase-3 and caspase-3. Taken together, cleaved caspase-3 and caspase-3 could be biomarkers for tumorigenesis in BMSCC patients. Cleaved caspase-3 and/or caspase-3 might be prognostic biomarkers for certain stages of BMSCC.

KEYWORDS:

buccal mucosa squamous cell carcinoma; caspase-3; cleaved caspase-3; prognosis; tumorigenesis

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

Supplemental Content

Full text links

Icon for Impact Journals, LLC Icon for PubMed Central
Loading ...
Support Center