Cancer Cell. 2017 Nov 13;32(5):544-545. doi: 10.1016/j.ccell.2017.10.010.

Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries.

Gomes J¹, Mereiter S¹, Magalhães A¹, Reis CA².

Author information

1: i3S - Institute for Research and Innovation in Health, University of Porto, 4200-135 Porto, Portugal; IPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, 4200-465 Porto, Portugal.
2: i3S - Institute for Research and Innovation in Health, University of Porto, 4200-135 Porto, Portugal; IPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, 4200-465 Porto, Portugal; Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal; Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal. Electronic address: celsor@ipatimup.pt.

Abstract

Glycosylation alterations are frequently observed in cancer cells and shape tumor progression. In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14.