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Nucleic Acids Res. 2018 Jan 4;46(D1):D661-D667. doi: 10.1093/nar/gkx1064.

WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research.

Author information

1
Department of Bioinformatics - BiGCaT, NUTRIM, Maastricht University, 6229 ER Maastricht, The Netherlands.
2
Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, 6229 ER Maastricht, The Netherlands.
3
Gladstone Institutes, San Francisco, California, CA 94158, USA.
4
University of Vienna, Department of Pharmaceutical Chemistry, 1090 Vienna, Austria.
5
Chair of Nutritional Physiology, Technische Universität München, 85350 Freising, Germany.
6
Laboratory for Biochemical Simulation, RIKEN Quantitative Biology Center, Suita, Osaka 565-0874, Japan.
7
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA.
8
Micelio, Antwerp, Belgium.
9
School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre, 6229 ER Maastricht, The Netherlands.

Abstract

WikiPathways (wikipathways.org) captures the collective knowledge represented in biological pathways. By providing a database in a curated, machine readable way, omics data analysis and visualization is enabled. WikiPathways and other pathway databases are used to analyze experimental data by research groups in many fields. Due to the open and collaborative nature of the WikiPathways platform, our content keeps growing and is getting more accurate, making WikiPathways a reliable and rich pathway database. Previously, however, the focus was primarily on genes and proteins, leaving many metabolites with only limited annotation. Recent curation efforts focused on improving the annotation of metabolism and metabolic pathways by associating unmapped metabolites with database identifiers and providing more detailed interaction knowledge. Here, we report the outcomes of the continued growth and curation efforts, such as a doubling of the number of annotated metabolite nodes in WikiPathways. Furthermore, we introduce an OpenAPI documentation of our web services and the FAIR (Findable, Accessible, Interoperable and Reusable) annotation of resources to increase the interoperability of the knowledge encoded in these pathways and experimental omics data. New search options, monthly downloads, more links to metabolite databases, and new portals make pathway knowledge more effortlessly accessible to individual researchers and research communities.

PMID:
29136241
PMCID:
PMC5753270
DOI:
10.1093/nar/gkx1064
[Indexed for MEDLINE]
Free PMC Article

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