Format

Send to

Choose Destination
Biomacromolecules. 2017 Dec 11;18(12):4292-4298. doi: 10.1021/acs.biomac.7b01335. Epub 2017 Nov 14.

Direct UV-Triggered Thiol-ene Cross-Linking of Electrospun Polyester Fibers from Unsaturated Poly(macrolactone)s and Their Drug Loading by Solvent Swelling.

Author information

1
Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland , 123 St. Stephens Green, Dublin 2, Ireland.
2
Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin 2, Ireland.
3
Tissue Engineering Research Group, Department of Anatomy & School of Pharmacy, Royal College of Surgeons in Ireland , Dublin 2, Ireland.
4
Advanced Materials and Bioengineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin , Dublin 2, Ireland.
5
Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin , Dublin 2, Ireland.
6
Anatomy, School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Ireland.

Abstract

Electrospinning is considered a relatively simple and versatile technique to form high porosity porous scaffolds with micron to nanoscale fibers for biomedical applications. Here, electrospinning of unsaturated aliphatic polyglobalide (PGl) into well-defined fibers with an average diameter of 9 μm is demonstrated. Addition of a dithiol cross-linker and a photoinitiator to the polymer solution enabled the UV-triggered intracross-linking of the fibers during the spinning process. The in situ cross-linking of the fibers resulted in amorphous material able to swell up to 14% in tetrahydrofurane (THF) without losing the fiber morphology. Seeding mesenchymal stem cells (MSCs) onto both cross-linked and non-cross-linked PGl fibers proved their compatibility with MSCs and suitability as scaffolds for cell growth and proliferation of MSCs. Moreover, the ability to directly load cross-linked PGl with hydrophobic molecules by soaking the fiber mesh in solution is shown with Rhodamine B and Indomethacin, a hydrophobic anti-inflammatory drug. This marks an advantage over conventional aliphatic polyesters and opens opportunities for the design of drug loaded polyester scaffolds for biomedical applications or tissue engineering.

PMID:
29134814
DOI:
10.1021/acs.biomac.7b01335
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center