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Sci Rep. 2017 Nov 13;7(1):15447. doi: 10.1038/s41598-017-15805-8.

Astrocyte elevated gene-1 promotes tumour growth and invasion by inducing EMT in oral squamous cell carcinoma.

Author information

1
Department of Dentistry, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
2
Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
3
Laboratory of Medical Genetics, Harbin MedicalUniversity, Harbin, 150081, China.
4
Department of Dentistry, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China. hrbwangmei@163.com.

Abstract

Oral squamous cell carcinoma (OSCC) is a common human malignancy with a high incidence rate and poor prognosis. Although astrocyte elevated gene 1 (AEG-1) expression is up-regulated in various human cancers and plays an important role in carcinogenesis and tumour progression, the impact of AEG-1 on the development and progression of OSCC remains unclear. Accordingly, this study aims to clarify the biological significance of AEG-1 in OSCC. We found AEG-1 to be overexpressed in OSCC tissues compared to normal oral mucosa. Knockdown or overexpression of AEG-1 in OSCC cell lines showed that AEG-1 is important for tumour growth, apoptosis, drug tolerance, and maintaining epithelial-mesenchymal transition (EMT)-mediated cell migration and invasion in vitro. Moreover, in a xenograft-mouse model generated by AEG-1-overexpressing SCC15 cells, we found that higher expression of AEG-1 promoted tumour growth, angiogenesis, and EMT in vivo. These findings provide mechanistic insight into the role of AEG-1 in regulating OSCC tumour growth, apoptosis, drug tolerance, and invasion, as well as AEG-1-induced activation of p38 and NF-κB signalling, suggesting that AEG-1 is an important prognostic factor and therapeutic target for OSCC.

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