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Microbes Infect. 2018 Mar;20(3):147-155. doi: 10.1016/j.micinf.2017.11.001. Epub 2017 Nov 10.

Evolution of the hygiene hypothesis into biota alteration theory: what are the paradigms and where are the clinical applications?

Author information

1
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
2
Department of Applied Ecology, North Carolina State University, Raleigh, NC 27607, USA.
3
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: William.Parker@Duke.edu.

Abstract

For thousands of years, changes in human cultures have altered the biota associated with the human body, and those alterations have strongly influenced human health. The hygiene hypothesis has evolved over the past 30 years into a nuanced biota alteration theory, but modern medical priorities and regulatory policies have resulted in tragic underutilization of the acquired knowledge.

KEYWORDS:

Biome; Biota; Helminth; Hygiene hypothesis; Microbiota

PMID:
29133248
DOI:
10.1016/j.micinf.2017.11.001
[Indexed for MEDLINE]

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