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Drug Discov Today. 2018 Feb;23(2):375-381. doi: 10.1016/j.drudis.2017.11.004. Epub 2017 Nov 10.

Galectin-3: mediator of microglia responses in injured brain.

Author information

1
Department of Psychiatry and Neuroscience, Faculty of Medicine, CERVO Brain Research Center, Laval University, Quebec, Quebec G1J 2G3, Canada.
2
Department of Psychiatry and Neuroscience, Faculty of Medicine, CERVO Brain Research Center, Laval University, Quebec, Quebec G1J 2G3, Canada; Faculty of Medicine, Department of Psychiatry and Neuroscience, Laval University, Québec, Québec, Canada. Electronic address: jasna.kriz@fmed.ulaval.ca.

Abstract

Galectin-3 is a pleiotropic protein involved in cell activation, proliferation and migration and plays a pivotal part as an inflammatory mediator in neurodegeneration. Galectin-3 is associated with microglial activation and proliferation after ischemia. Given its putative role as a dynamic fine-tuner of microglia, activation of Galectin-3 provides molecular cues in design of new immunomodulatory strategies for stroke management. This review summarizes recent evidence on the role of Galectin-3 as a mediator of immune responses in damaged brain and mechanisms employed by Galectin-3 to affect microglial function.

PMID:
29133191
DOI:
10.1016/j.drudis.2017.11.004
[Indexed for MEDLINE]

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