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Immunol Allergy Clin North Am. 2018 Feb;38(1):27-37. doi: 10.1016/j.iac.2017.09.003. Epub 2017 Oct 26.

Oral Tolerance Development and Maintenance.

Author information

1
Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA. Electronic address: ewambre@benaroyaresearch.org.
2
Virginia Mason Medical Center, 1201 Terry Avenue, Seattle, WA 98101, USA.

Abstract

The gastrointestinal tract has an abundant mucosal immune system to develop and maintain oral tolerance. The oral route of administration takes advantage of the unique set of immune cells and pathways involved in the induction of oral tolerance. Food allergy results from a loss of oral tolerance toward ingested antigens. Oral immunotherapy is thought to initiate desensitization through interaction of an allergen with mucosal dendritic cells that initiate downstream immune system modulation through regulatory T cells and effector T cells.

KEYWORDS:

CD4(+) T cells; Dendritic cells; Food allergy; Immune tolerance; Immunotherapy; Microbiome; Mucosal immunity

PMID:
29132672
PMCID:
PMC5776674
[Available on 2019-02-01]
DOI:
10.1016/j.iac.2017.09.003
[Indexed for MEDLINE]

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