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Nat Prod Res. 2018 Aug;32(15):1769-1774. doi: 10.1080/14786419.2017.1402315. Epub 2017 Nov 13.

A novel xanthone dimer derivative with antibacterial activity isolated from the bark of Garcinia mangostana.

Wang W1,2,3, Liao Y1,2,4, Huang X1,2,4, Tang C1,2,4, Cai P1,2,4.

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a Key Laboratory of Urban Environment and Health, Institute of Urban Environment , Chinese Academy of Sciences , Xiamen , P. R. China.
b University of Chinese Academy of Sciences , Beijing , P. R. China.
c State Key Laboratory Breeding Base of Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources , Fujian Collaborative Innovation Centre for Exploitation and Utilization of Marine Biological Resources, Third Institute of Oceanography, State Oceanic Administration , Xiamen , P. R. China.
d Xiamen Key Laboratory of Physical Environment , Xiamen , P. R. China.


A novel xanthone dimer derivative, garmoxanthone (1), together with 10 known compounds (2-11), were isolated from bark of Garcinia mangostana. Their structures were established through spectroscopic methods. Garmoxanthone exhibited strong inhibitory activities against MRSA ATCC 43300 and MRSA CGMCC 1.12409 (with MIC values of both 3.9 μg/mL) and moderate activities against tested strains of Vibrio (with MIC values ranging from 15.6 to 31.2 μg/mL). Garmoxanthone is a unique xanthone dimer with linkage of a fused 5/6 ring system and its absolute configuration was elucidated on the basis of experimental and calculated electronic circular dichroism. Garmoxanthone exhibited strong antibacterial activity which partially validated the ethnobotanical use of G. mangostana in the treatment of infections.


Garcinia mangostana; antibacterial; garmoxanthone; xanthone dimer

[Indexed for MEDLINE]

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