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Sichuan Da Xue Xue Bao Yi Xue Ban. 2017 Jul;48(4):566-569.

[Expression of LOX in Colorectal Cancer Tissues and Its Relationship with Progress and Prognosis].

[Article in Chinese]

Author information

1
Department of General Surgery, Hebei General Hospital, Shijiazhuang 050051, China.

Abstract

OBJECTIVE:

To analyze the expression of lysyl oxidase (LOX) in colorectal cancer and its relationship with clinicopathological characteristics, prognosis, and its progress.

METHODS:

82 cases of colorectal tumor paraffin-embedded specimens and paired tumor-adjacent tissues were collected, and data of clinicopathological characteristics and prognosis of these patients were also recorded from 2009.1 to 2010.5. Expressions of LOX, hypoxia inducible factor-1α (HIF-1α), matrix metalloproteinase (MMP)-2, MMP-7 were determined by immunohistochemistry. Then relationship between LOX and clinicopathological characteristics and prognosis was explored, and relationship between LOX and HIF-1α, MMP-2, MMP-7 were investigated.

RESULTS:

Expressions of LOX was stronger in tumors than in tumor-adjacent tissues (P<0.05). Cancer tissues with overexpressed LOX had later clinical stages, deeper tumor invasion, and more metastatic lymph nodes (all P<0.05). The result also showed that patients with overexpression of LOX had poorer prognosis, and overexpression of LOX was independent factor for prognosis in COX survival analysis. Expression of HIF-1α, MMP-2, MMP-7 in colorectal cancer was stronger than in tumor-adjacent tissues (P<0.05). Positive relationship was found between LOX and HIF-1α, MMP-2, MMP-7 proteins (P<0.05).

CONCLUSION:

LOX was overexpressed in colorectal cancer tissues, and was associated with the progression of colorectal cancer. LOX may be involved in the progress of colorectal cancer by regulating HIF-1α, MMP-2, MMP-7 protein expression.

KEYWORDS:

Clinicopathological characteristics ; Colorectal cancer ; Invasion, metastasis ; Lysyl oxidase (LOX) gene ; Prognosis

PMID:
29130678

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