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J Appl Microbiol. 2018 Mar;124(3):821-828. doi: 10.1111/jam.13635. Epub 2018 Jan 28.

Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 alleviates birch pollen-induced allergic rhinitis in mice.

Author information

1
Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Korea.
2
CJ CheilJedang Corporation, Suwon-si, Korea.
3
Department of Biomedical Laboratory Science, College of Health Science, Cheongju University, Cheongju-si, Korea.

Abstract

AIMS:

In this study, we evaluated the therapeutic efficacy of selected probiotics in a mouse model of birch pollen (BP)-induced allergic rhinitis.

METHODS AND RESULTS:

Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 ameliorated the symptoms of BP-induced allergic rhinitis by reducing airway hyperresponsiveness, and both the histological scores and the number of infiltrated cells in the nasal cavities and lungs. Compared with those from vehicle-treated mice, bronchoalveolar lavage fluid and draining lymph node samples from CJLP133 and CJLP243-administrated mice showed diminished numbers of immune cells, increased secretion of a Th1-type cytokine (IFN-γ) and decreased production of Th2-type cytokines (IL-4, IL-5 and IL-13). Consistent with these results, levels of IL-4, IL-5, IL-13, serum IgE and BP-specific serum IgG1 were decreased, whereas secretion of IFN-γ and BP-specific serum IgG2a was augmented upon administration of CJLP133 and CJLP243 in mice.

CONCLUSION:

Oral administration of L. plantarum CJLP133 and CJLP243 alleviates symptoms of BP-induced allergic rhinitis in mice by recovering Th1/Th2 balance via enhancement of the Th1-type immune response.

SIGNIFICANCE AND IMPACT OF THE STUDY:

Lactobacillus plantarum CJLP133 and CJLP243 have therapeutic effects on BP-induced allergic rhinitis in an animal model.

KEYWORDS:

Lactobacillus plantarum ; CJLP133; CJLP243; allergic rhinitis; birch pollen

PMID:
29130606
DOI:
10.1111/jam.13635
[Indexed for MEDLINE]

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