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Nat Prod Res. 2017 Nov 13:1-17. doi: 10.1080/14786419.2017.1399387. [Epub ahead of print]

Medicinal properties of alpha-santalol, a naturally occurring constituent of sandalwood oil: review.

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a Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy , Wilkes University , Wilkes-Barre , PA , USA.
b Department of Pharmaceutical Sciences, College of Pharmacy , South Dakota State University , Brookings , South Dakota.


Alpha-santalol is a naturally occurring sesquiterpene that is derived from sandalwood oil. Its wide range of health benefits have been attributed to the modulation of various signalling pathways involved in the development of a particular disease. For example, the antitumour and cancer preventive properties of alpha-santalol have been shown to involve cell death induction through apoptosis and cell cycle arrest in various cancer models. A marked decrease in inflammatory markers have also been shown with alpha-santalol administration in skin tissue models. The current review is aimed at bringing the most recent advances of alpha-santalol against various disease-specific models and highlighting its associated mechanistic details.


Alpha-santalol; apoptosis; cancer; diabetes; inflammation

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