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Adv Exp Med Biol. 2017;1016:157-178. doi: 10.1007/978-3-319-63904-8_9.

The Future of CRISPR Applications in the Lab, the Clinic and Society.

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Department of Microbiology, University of Massachusetts Amherst, 418 Morrill Science Center IVN, 649 North Pleasant Street, Amherst, MA, 01003, USA.
Department of Clinical Medicine, St. James' Hospital, Dublin, Ireland, James's Street, Dublin 8, Dublin, Leinster, D08 NHY1, Ireland.


CRISPR (clustered regularly interspaced short palindromic repeats) has emerged as one of the premiere biological tools of the century. Even more so than older genome editing techniques such as TALENs and ZFNs, CRISPR provides speed and ease-of-use heretofore unheard of in agriculture, the environment and human health. The ability to map the function of virtually every component of the genome in a scalable, multiplexed manner is unprecedented. Once those regions have been explored, CRISPR also presents an opportunity to take advantage of endogenous cellular repair pathways to change and precisely edit the genome [1-3]. In the case of human health, CRISPR operates as both a tool of discovery and a solution to fundamental problems behind disease and undesirable mutations.


Agriculture; Biodiversity; Bioethics; CRISPR; Germline; Medicine; Next-generation sequencing; Regulation

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