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J Ophthalmol. 2017;2017:7174540. doi: 10.1155/2017/7174540. Epub 2017 Oct 9.

Changes in Retinal and Choroidal Vascular Blood Flow after Oral Sildenafil: An Optical Coherence Tomography Angiography Study.

Author information

1
Ophthalmology Department, Asociación para Evitar la Ceguera en México IAP, Mexico City, Mexico.
2
Retina Department, Asociación para Evitar la Ceguera en México IAP, Mexico City, Mexico.

Abstract

Purpose:

To describe changes in the retina and choroidal flow by optical coherence tomography angiography (OCT-A) after a single dose of oral sildenafil.

Method:

A case-control study. Patients in the study group received 50 mg of oral sildenafil. Patients in the control group received a sham pill. Retinal and choroidal images were obtained at baseline (before pill ingestion) and 1 hour after ingestion. Central macular and choroidal thickness, choroidal and outer retina flow, and the retinal and choroidal vascular density were compared using a Mann-Whitney U test.

Results:

Twenty eyes were enrolled into the study group and 10 eyes in the control group. There was a significant difference in central choroidal thickness and outer retina blood flow between groups after 1 hour of sildenafil ingestion (p < 0.01). There were no differences in central macular thickness, choroidal flow, and retinal vascular density among groups.

Conclusions:

A single dose of oral sildenafil increases choroidal thickness, probably due to sildenafil-induced vasodilation.

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