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J Pediatr. 2018 Jan;192:259-261. doi: 10.1016/j.jpeds.2017.09.024. Epub 2017 Nov 9.

Is Serum Methylmalonic Acid a Reliable Biomarker of Vitamin B12 Status in Children with Short Bowel Syndrome: A Case Series.

Author information

1
Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA; Center for Advanced Intestinal Rehabilitation, Boston Children's Hospital, Harvard Medical School, Boston, MA. Electronic address: lissette.jimenez@childrens.harvard.edu.
2
Center for Advanced Intestinal Rehabilitation, Boston Children's Hospital, Harvard Medical School, Boston, MA; Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA.
3
Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA; Center for Advanced Intestinal Rehabilitation, Boston Children's Hospital, Harvard Medical School, Boston, MA.

Abstract

We describe 3 patients with short bowel syndrome who had persistently elevated serum methylmalonic acid (MMA) levels while being treated for vitamin B12 deficiency. Following treatment for presumed small bowel bacterial overgrowth, MMA levels normalized. Among patients with short bowel syndrome, MMA levels may have limited specificity for vitamin B12 deficiency.

KEYWORDS:

methylmalonic acid; short bowel syndrome; small bowel bacterial overgrowth; vitamin B12 deficiency

PMID:
29129351
PMCID:
PMC6029886
DOI:
10.1016/j.jpeds.2017.09.024
[Indexed for MEDLINE]
Free PMC Article

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