Format

Send to

Choose Destination
Nutrition. 2018 Jan;45:1-10. doi: 10.1016/j.nut.2017.06.027. Epub 2017 Jul 13.

Preoperative low muscle mass has a strong negative effect on pulmonary function in patients undergoing living donor liver transplantation.

Author information

1
Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
2
Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: kaido@kuhp.kyoto-u.ac.jp.

Abstract

OBJECTIVE:

This study investigated the effect of preoperative sarcopenia on cardiopulmonary function in patients undergoing living donor liver transplantation (LDLT).

METHODS:

A retrospective analysis was performed of 207 patients who underwent LDLT between January 2008 and April 2015. The quantity and quality of skeletal muscle were evaluated by the psoas muscle mass index (PMI) and intramuscular adipose tissue content (IMAC), respectively, using preoperative computed tomography imaging. The correlations between preoperative cardiopulmonary function and sarcopenic factors (PMI, IMAC, and grip strength [GS]) were examined. Moreover, overall survival (OS) rates according to preoperative pulmonary function and risk factors were analyzed.

RESULTS:

No significant differences were found between ejection fraction (EF) and these sarcopenic factors. In contrast, preoperative vital capacity (VC) and forced expiratory volume (FEV) 1.0 were significantly correlated with PMI (P < 0.001, P < 0.001), IMAC (P = 0.024, P = 0.013), and GS (P = 0.006, P = 0.033) in males. Preoperative VC and FEV1.0 were significantly correlated with IMAC (P = 0.002, P = 0.001) and GS (P = 0.002, P = 0.001) in females. Moreover, %VC, VC, and FEV1.0 in the preoperative low muscle mass group were significantly lower than in the normal muscle mass group (P = 0.004, P < 0.001, P < 0.001, respectively) in males. Multivariate analysis revealed that preoperative low PMI and preoperative restrictive ventilatory impairment were independent risk factors (P = 0.046 and P = 0.014, respectively).

CONCLUSIONS:

Preoperative low muscle mass was closely involved with pulmonary dysfunction in patients undergoing LDLT.

KEYWORDS:

Cardiopulmonary function; Intramuscular adipose tissue content; Liver transplantation; Psoas muscle mass index; Sarcopenia

PMID:
29129228
DOI:
10.1016/j.nut.2017.06.027
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center