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Pharmacol Rep. 2017 Dec;69(6):1194-1205. doi: 10.1016/j.pharep.2017.07.002. Epub 2017 Jul 4.

Beneficial roles of honey polyphenols against some human degenerative diseases: A review.

Author information

1
Laboratory of Preventive and Integrative Biomedicine, Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka, Bangladesh. Electronic address: sakibhossen00@gmail.com.
2
Laboratory of Preventive and Integrative Biomedicine, Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka, Bangladesh. Electronic address: yousufbmb40ju@gmail.com.
3
Faculty of Food Science and Nutrition, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia. Electronic address: jahurulhaque@yahoo.com.
4
Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt; Department of Ophthalmology and Micro-Technology, Yokohama City University, Yokohama, Japan. Electronic address: abdeldaim.m@vet.suez.edu.eg.
5
Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. Electronic address: shgan@usm.my.
6
Laboratory of Preventive and Integrative Biomedicine, Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka, Bangladesh; Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. Electronic address: drmikhalil@gmail.com.

Abstract

Honey contains many active constituents and antioxidants such as polyphenols. Polyphenols are phytochemicals, a generic term for the several thousand plant-based molecules with antioxidant properties. Many in vitro studies in human cell cultures as well as many animal studies confirm the protective effect of polyphenols on a number of diseases such as cardiovascular diseases (CVD), diabetes, cancer, neurodegenerative diseases, pulmonary diseases, liver diseases and so on. Nevertheless, it is challenging to identify the specific biological mechanism underlying individual polyphenols and to determine how polyphenols impact human health. To date, several studies have attempted to elucidate the molecular pathway for specific polyphenols acting against particular diseases. In this review, we report on the various polyphenols present in different types of honey according to their classification, source, and specific functions and discuss several of the honey polyphenols with the most therapeutic potential to exert an effect on the various pathologies of some major diseases including CVD, diabetes, cancer, and neurodegenerative diseases.

KEYWORDS:

Antioxidants; CVD; Cancer; Diabetes; Honey; Neurodegenerative disease; Polyphenols

PMID:
29128800
DOI:
10.1016/j.pharep.2017.07.002
[Indexed for MEDLINE]

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