Format

Send to

Choose Destination
Biochem Biophys Res Commun. 2018 Jan 1;495(1):614-620. doi: 10.1016/j.bbrc.2017.10.154. Epub 2017 Nov 9.

Scavenger receptor class B type 1 regulates neuroblastoma cell proliferation, migration and invasion.

Author information

1
Department of Physiology and Anatomy, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, Tx, 76107, USA. Electronic address: Marlyn.Panchoo@live.unthsc.edu.
2
Department of Physiology and Anatomy, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, Tx, 76107, USA. Electronic address: Andras.Lacko@unthsc.edu.

Abstract

Neuroblastoma (NB) is an extra cranial pediatric embryonal tumor most prevalent in children less than 1 year of age. NB accounts for 7% of all pediatric cancers but accounts for 15% of all childhood cancer deaths. Scavenger receptor class B type 1 (SR-B1), a mediator of cellular cholesterol uptake, is overexpressed in and have been linked to the aggressiveness of many cancers. Nevertheless, no studies have so far investigated the relationship between SR-B1 and NB. Elucidation of receptors that promote NB may pave the way for discovery of new therapeutic targets. Here we show that inhibition of SR-B1 reduced cell survival, migration and invasion, and cholesterol content in NB cell lines. Additionally analysis of SR-B1 levels in NB patient biopsies using the R2: Genomics Analysis and Visualization Platform showed that high SR-B1 expression correlated with decreased overall and event-free survival.

KEYWORDS:

Cholesterol metabolism; Neuroblastoma; Scavenger receptor class B type 1

PMID:
29128352
DOI:
10.1016/j.bbrc.2017.10.154
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center