Cost-effective flow cytometry (FC) requires development of FC panels focused to common diagnoses and strategies to identify cases where limited FC testing is sufficient. Focused panels include sufficient antibodies and to identify common diseases and appropriate analysis strategies to identify rare diseases that need additional FC testing. Strategies to limit FC testing include the use of algorithms to predict disease probability, with limited FC performed if disease is unlikely. Successful algorithms use easily available parameters, have well-defined rules for use, and are periodically reviewed and updated to maximize efficiency while containing costs.
Keywords: Evidence-based laboratory medicine; Flow cytometry; Laboratory test algorithms; Laboratory test utilization; Physician education.
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