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Sci Rep. 2017 Nov 10;7(1):15253. doi: 10.1038/s41598-017-15524-0.

Margination of Stiffened Red Blood Cells Regulated By Vessel Geometry.

Author information

1
State Key Laboratory of Tribology, Tsinghua University, Beijing, 100084, China.
2
Department of Microsystem Engineering, Rochester Institute of Technology, Rochester, NY, 14623, USA.
3
School of Mechanical Engineering, University of Science and Technology Beijing, Beijing, 100083, China.
4
State Key Laboratory of Tribology, Tsinghua University, Beijing, 100084, China. chenhs@tsinghua.edu.cn.

Abstract

Margination of stiffened red blood cells has been implicated in many vascular diseases. Here, we report the margination of stiffened RBCs in vivo, and reveal the crucial role of the vessel geometry in the margination by calculations when the blood is seen as viscoelastic fluid. The vessel-geometry-regulated margination is then confirmed by in vitro experiments in microfluidic devices, and it establishes new insights to cell sorting technology and artificial blood vessel fabrication.

PMID:
29127352
PMCID:
PMC5681636
DOI:
10.1038/s41598-017-15524-0
[Indexed for MEDLINE]
Free PMC Article

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