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Neuroimage. 2018 Feb 1;166:293-306. doi: 10.1016/j.neuroimage.2017.10.048. Epub 2017 Nov 7.

Brain state expression and transitions are related to complex executive cognition in normative neurodevelopment.

Author information

1
Department of Psychology, Drexel University, Philadelphia, PA 19104, USA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2
Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
3
Department of Psychology, Drexel University, Philadelphia, PA 19104, USA.
4
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Electrical & Systems Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: dsb@seas.upenn.edu.

Abstract

Adolescence is marked by rapid development of executive function. Mounting evidence suggests that executive function in adults may be driven by dynamic control of neurophysiological processes. Yet, how these dynamics evolve over adolescence and contribute to cognitive development is unknown. In a sample of 780 youth aged 8-22 yr (42.7% male) from the Philadelphia Neurodevelopment Cohort, we use a dynamic graph approach to extract activation states in BOLD fMRI data from 264 brain regions. We construct a graph in which each observation in time is a node and the similarity in brain states at two different times is an edge. Using this graphical approach, we identify two primary brain states reminiscent of intrinsic and task-evoked systems. We show that time spent in these two states is higher in older adolescents, as is the flexibility with which the brain switches between them. Increasing time spent in primary states and flexibility among states relates to increases in a complex executive accuracy factor score over adolescence. Flexibility is more positively associated with accuracy toward early adulthood. These findings suggest that brain state dynamics are associated with complex executive function across a critical period of adolescence.

PMID:
29126965
PMCID:
PMC5747984
[Available on 2019-02-01]
DOI:
10.1016/j.neuroimage.2017.10.048
[Indexed for MEDLINE]
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