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Am J Med. 2018 Mar;131(3):226-236. doi: 10.1016/j.amjmed.2017.10.033. Epub 2017 Nov 7.

Autoimmune Neurologic Disorders.

Author information

1
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Electronic address: drubin4@partners.org.
2
Ken & Ruth Davee Department of Neurology, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Ill.
3
Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.

Abstract

The practice of autoimmune neurology focuses on the diagnosis and treatment of a wide spectrum of neurological conditions driven by abnormal immune responses directed against neural tissues. These include autoimmune, paraneoplastic, postinfectious, and iatrogenic conditions. Symptoms of autoimmune neurologic disorders can be diverse and often difficult to recognize in their early stages, complicating the diagnosis. This review discusses the classification and management of common autoimmune neurological conditions, placing an emphasis on the rapid identification of autoimmune etiology and mechanism of immune dysfunction to allow for the timely institution of appropriate treatment.

KEYWORDS:

Autoantibodies; Autoimmune neurology; Encephalitis; Immunotherapy; Paraneoplastic disorders

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