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Neurosci Lett. 2018 Jan 18;664:38-42. doi: 10.1016/j.neulet.2017.11.008. Epub 2017 Nov 7.

Effects of acupuncture on the anxiety-like behavior induced by withdrawal from chronic morphine use.

Author information

1
Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu, 42158, Republic of Korea.
2
School of Mental Health, Qiqihar Medical University, Qiqihar, Heilongjiang Province, 161006, China.
3
Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, 42158, Republic of Korea.
4
Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu, 42158, Republic of Korea. Electronic address: now123@dreamwiz.com.
5
Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu, 42158, Republic of Korea. Electronic address: dlqhdgy@dhu.ac.kr.

Abstract

OBJECTIVES:

In the previous studies, it has been demonstrated that acupuncture treatment was effective on the suppression of withdrawal signs as well as self-administration behavior induced by morphine. Based on, the present study has investigated whether acupuncture could attenuate the anxiety-like behavior induced by withdrawal from chronic morphine treatment.

MATERIALS & METHODS:

Male Sprague-Dawley rats weighing 270-300g were treated saline or morphine hydrochloride (10mg/kg, s.c.) for 2 weeks. Following abstinence of 5days in home cage, rats were subjected to the measurement of anxiety-like behavior in the elevated plus maze. Bicuculline (1mg/kg, i.p.) and SCH 50911 (2mg/kg, i.p.) were used to investigate the possible mechanism of acupuncture effects focusing on the GABA receptors system.

RESULTS:

Acupuncture at HT7 increased the time spent in open arms significantly. Also, these effects of acupuncture at HT7 were blocked by GABAA receptor antagonist.

CONCLUSION:

Results of the present study suggest that acupuncture at HT7 can attenuate anxiety-like behavior induced by withdrawal from chronic morphine treatment through the mediation of GABAA receptor system.

KEYWORDS:

Acupuncture; Anxiety; GABA; HT7; Morphine

PMID:
29126776
DOI:
10.1016/j.neulet.2017.11.008
[Indexed for MEDLINE]

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