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Environ Pollut. 2018 Feb;233:706-713. doi: 10.1016/j.envpol.2017.10.127. Epub 2017 Nov 7.

Environmental concentrations and toxicology of 2,4,6-tribromophenol (TBP).

Author information

1
Aquatic Ecology and Centre for Water and Environmental Research (ZWU), University Duisburg-Essen, 45141 Essen, Germany; Deutsche Rockwool GmbH & Co. KG, 45966 Gladbeck, Germany. Electronic address: christoph.koch@uni-due.de.
2
Aquatic Ecology and Centre for Water and Environmental Research (ZWU), University Duisburg-Essen, 45141 Essen, Germany.

Abstract

2,4,6-Tribromophenol is the most widely produced brominated phenol. In the present review, we summarize studies dealing with this substance from an environmental point of view. We cover concentrations in the abiotic and biotic environment including humans, toxicokinetics as well as toxicodynamics, and show gaps of the current knowledge about this chemical. 2,4,6-Tribomophenol occurs as an intermediate during the synthesis of brominated flame retardants and it similarly represents a degradation product of these substances. Moreover, it is used as a pesticide but also occurs as a natural product of some aquatic organisms. Due to its many sources, 2,4,6-tribromophenol is ubiquitously found in the environment. Nevertheless, not much is known about its toxicokinetics and toxicodynamics. It is also unclear which role the structural isomer 2,4,5-tribromophenol and several degradation products such as 2,4-dibromophenol play in the environment. Due to new flame retardants that enter the market and can degrade to 2,4,6-tribromophenol, this compound will remain relevant in future years - not only in aquatic matrices, but also in house dust and foodstuff, which are an important exposure route for humans.

KEYWORDS:

Concentrations; Humans; Sources; Toxicology; Tribromophenol

PMID:
29126092
DOI:
10.1016/j.envpol.2017.10.127
[Indexed for MEDLINE]

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