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Cancer. 1989 Feb 1;63(3):438-9.

Jaundice and intrahepatic cholestasis following high-dose megestrol acetate for breast cancer.

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Department of Pathology, Columbia University College of Physicians and Surgeons, NY 10032.


High-dose megestrol acetate, a synthetic progestin, has been advocated recently in treating patients with metastatic breast carcinoma; no significant increase in adverse effects has been reported. This report describes a patient with jaundice and intrahepatic cholestasis after high-dose megestrol acetate therapy. This cholestatic lesion may have a pathogenesis similar to that observed with estrogens and oral contraceptives.

[Indexed for MEDLINE]

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