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Adv Exp Med Biol. 2017;996:221-230. doi: 10.1007/978-3-319-56017-5_18.

Vitamin D, Cardiovascular Disease and Risk Factors.

Author information

1
Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup Hospital, Nordre Ringvej 57, DK-2600, Glostrup, Denmark. tea.skaaby.01@regionh.dk.
2
Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup Hospital, Nordre Ringvej 57, DK-2600, Glostrup, Denmark.
3
Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.
4
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Abstract

Observational studies have suggested a possible protective role of vitamin D on the cardiovascular system. The available evidence does not support either cardiovascular benefits or harms of vitamin D supplementation. This chapter provides an overview and discussion of the current knowledge of vitamin D effects from a cardiovascular health perspective. It focuses on vitamin D in relation to cardiovascular disease, i.e. ischemic heart disease, and stroke; the traditional cardiovascular risk factors hypertension, abnormal blood lipids, obesity; and the emerging risk factors hyperparathyroidism, microalbuminuria, chronic obstructive pulmonary diseases, and non-alcoholic fatty liver disease. Meta-analyses of observational studies have largely found vitamin D levels to be inversely associated with cardiovascular risk and disease. However, Mendelian randomization studies and randomized, controlled trials (RCTs) have not been able to consistently replicate the observational findings. Several RCTs are ongoing, and the results from these are needed to clarify whether vitamin D deficiency is a causal and reversible factor to prevent cardiovascular disease.

KEYWORDS:

Cardiovascular disease; Chronic obstructive pulmonary disease; Diabetes; Fatty liver disease; Hypercholesterolemia; Hyperparathyroidism; Hypertension; Microalbuminuria; Obesity; Vitamin D

PMID:
29124703
DOI:
10.1007/978-3-319-56017-5_18
[Indexed for MEDLINE]

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