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Endosc Int Open. 2017 Nov;5(11):E1128-E1135. doi: 10.1055/s-0043-118096. Epub 2017 Nov 8.

Patient decision-making and clinical outcomes following endoscopic therapy or esophagectomy for Barrett's neoplasia.

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Division of Gastroenterology, Hepatology & Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA.
The Dartmouth Institute, Hanover, NH, USA.
Harvard Medical School, Institute for Technology Assessment and Gastrointestinal Unit, Boston, MA, USA.


Background and study aims:

 The objective of this study was to assess patient involvement in decision-making, decision confidence, and decision regret among patients who had undergone endoscopic eradication therapy (EET) or esophagectomy for Barrett's esophagus (BE) associated neoplasia.

Patients and methods:

 Patients with BE high grade dysplasia or intramucosal (T1a) adenocarcinoma who had undergone EET or esophagectomy were invited to complete a survey.


 The cohort included 50 subjects, 70 % (35/50) of whom had undergone EET and 30 % (15/50) of whom had undergone esophagectomy. Subjects who underwent esophagectomy were more likely to report post-treatment dysphagia (47 % vs 14 %, P  = 0.03), post-treatment dietary modification (73 % vs 6 %, P  < 0.0001), and were less likely to view their post-treatment health favorably. However, when asked whether they had selected the right treatment, a high degree of confidence was reported by both groups (mean 9.8 for EET vs 9.3 for esophagectomy on a 0 - 10 scale, P  = 0.12). In fact, 97 % (34/35) of EET patients and 80 % (12/15) of esophagectomy patients indicated they would select the same treatment option ( P  = 0.08).


 Patients who have undergone EET or surgery for BE neoplasia report a high degree of involvement in the decision-making process. Although EET patients report fewer symptom-specific outcomes, measures of decision confidence and decision regret do not differ between the two treatment groups.

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