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Acute Med Surg. 2014 Dec 11;2(3):214-218. doi: 10.1002/ams2.103. eCollection 2015 Jul.

Paralytic ileus induced by glyphosate intoxication successfully treated using Kampo medicine.

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Department of Emergency and Critical Care Medicine Akita University Graduate School of Medicine Akita Japan.



A 65-year-old woman ingested glyphosate-surfactant herbicide in an attempt to commit suicide. She experienced glyphosate intoxication associated with multiple organ failure and developed a paralytic ileus. Daijokito, a traditional Japanese Kampo medicine was given to the patient to improve constipation and psychological symptoms. Next, rikkunshito was given to increase her gastric motility. Finally, daikenchuto was given to improve overall digestive peristalsis.


All abdominal symptoms ultimately improved after treatment with daikenchuto.


Kampo medicines may help improve abdominal symptoms associated with glyphosate intoxication in cases where modern medical treatment alone proves inadequate.


Daikenchuto; glyphosate–surfactant herbicide; multiple organ failure; paralytic ileus; traditional Japanese herbal medicine

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