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Sci Rep. 2017 Nov 9;7(1):15216. doi: 10.1038/s41598-017-15152-8.

Genomic and epidemiological characterisation of a dengue virus outbreak among blood donors in Brazil.

Author information

1
Department of Zoology, University of Oxford, Oxford, United Kingdom. nuno.faria@zoo.ox.ac.uk.
2
Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, Brazil. charlysbr@yahoo.com.br.
3
LIM46, Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. charlysbr@yahoo.com.br.
4
Department of Zoology, University of Oxford, Oxford, United Kingdom.
5
Faculdade de Ciências Médicas, Fundação Hemope, Recife, Brazil.
6
Fundação Hemório, Rio de Janeiro, Brazil.
7
Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, Brazil.
8
LIM46, Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
9
Laboratório de Investigação Médica LIM03, Hospital das Clínicas, Sao Paulo, Brazil.
10
Institut de Recherche pour le Développement, Université de Montpellier, Montpellier, France.
11
Department of Statistics, University of Oxford, Oxford, United Kingdom.
12
Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
13
Division of Infectious Diseases, University of Toronto, Toronto, Ontario, Canada.
14
Blood Systems Research Institute, San Francisco, California, USA.
15
University of California San Francisco, San Francisco, California, USA.
16
Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, Brazil. sabinoec@usp.br.
17
LIM46, Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. sabinoec@usp.br.

Abstract

Outbreaks caused by Dengue, Zika and Chikungunya viruses can spread rapidly in immunologically naïve populations. By analysing 92 newly generated viral genome sequences from blood donors and recipients, we assess the dynamics of dengue virus serotype 4 during the 2012 outbreak in Rio de Janeiro. Phylogenetic analysis indicates that the outbreak was caused by genotype II, although two isolates of genotype I were also detected for the first time in Rio de Janeiro. Evolutionary analysis and modelling estimates are congruent, indicating a reproduction number above 1 between January and June, and at least two thirds of infections being unnoticed. Modelling analysis suggests that viral transmission started in early January, which is consistent with multiple introductions, most likely from the northern states of Brazil, and with an increase in within-country air travel to Rio de Janeiro. The combination of genetic and epidemiological data from blood donor banks may be useful to anticipate epidemic spread of arboviruses.

PMID:
29123142
PMCID:
PMC5680240
DOI:
10.1038/s41598-017-15152-8
[Indexed for MEDLINE]
Free PMC Article

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