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Nutr Metab Cardiovasc Dis. 2018 Jan;28(1):71-76. doi: 10.1016/j.numecd.2017.09.008. Epub 2017 Oct 3.

Serum Fetuin-A levels in obese children with biopsy proven nonalcoholic fatty liver disease.

Author information

1
Department of Women's and Children's Health, Pediatric Endocrinology Unit, Karolinska Institutet and University Hospital, 17176, Stockholm, Sweden. Electronic address: valentina.pampanini@ki.se.
2
Dipartimento Pediatrico Universitario Ospedaliero "Bambino Gesù" Children's Hospital - Tor Vergata University, 00165, Rome, Italy.
3
Department of Systems Medicine, Tor Vergata University, 00173, Rome, Italy.
4
Hepato-Metabolic Disease Unit, "Bambino Gesù" Children's Hospital - IRCCS, Rome, Italy.
5
Department of Women's and Children's Health, Pediatric Endocrinology Unit, Karolinska Institutet and University Hospital, 17176, Stockholm, Sweden; Dipartimento Pediatrico Universitario Ospedaliero "Bambino Gesù" Children's Hospital - Tor Vergata University, 00165, Rome, Italy.

Abstract

BACKGROUND AND AIMS:

Fetuin-A has been proposed as a marker of liver damage in adults with obesity-related NAFLD. The aim of this study was to test serum fetuin-A concentrations in obese children with NAFLD diagnosed either by ultrasonography or by liver biopsy and to determine its applicability as predictive tool in pediatric NAFLD.

METHODS AND RESULTS:

Metabolic parameters and fetuin-A levels were investigated in 81 obese children with NAFLD diagnosed by biopsy, 79 obese children with NAFLD defined by liver ultrasonography and 23 lean subjects. Serum fetuin-A correlated significantly with age, waist circumference, systolic blood pressure, fasting insulin and 2-h postload insulin during OGTT, HOMA-IR, ISI, CRP, and apo B levels. Obese children with NAFLD detected by ultrasonography had significantly higher fetuin-A levels compared to those with normal liver. In obese children who underwent liver biopsy, no significant differences were detected in fetuin-A levels between subject with nonalcoholic steatohepatitis and those with simple steatosis. Fetuin-A was not different between obese and lean children.

CONCLUSION:

Fetuin-A is not related with the degree of liver damage in obese children with NAFLD and its routine measurement as marker of liver disease severity is therefore not recommended.

KEYWORDS:

Children; Fetuin-A; NAFLD; Nonalcoholic fatty liver disease; Obesity

PMID:
29122442
DOI:
10.1016/j.numecd.2017.09.008
[Indexed for MEDLINE]

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